TNIP3 antibody (C-Term)

Catalog No. ABIN499187

The Rabbit Polyclonal anti-TNIP3 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect TNIP3 in samples from Human and Mouse.

Quick Overview for TNIP3 antibody (C-Term) (ABIN499187)

Target: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TNIP3 Antibody

Binding Specificity: C-Term

Specificity: This antibody reactcs to ABIN3 near the carboxy terminus.

Purification: Affinity chromatography purified via peptide column

Immunogen: ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ABIN3 antibody can be used for detection of ABIN3 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TNIP3

Target: TNIP3 (TNFAIP3 Interacting Protein 3 (TNIP3))

Alternative Name: TNIP3

Background: The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.Synonyms: A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN3, LIND, Listeria-induced gene protein, TNFAIP3-interacting protein 3

Gene ID: 79931

NCBI Accession: NP_079149

UniProt: Q96KP6

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin