ABCA7 antibody (AA 251-350) (AbBy Fluor® 750)

Catalog No. ABIN4995862

The Rabbit Polyclonal anti-ABCA7 antibody has been validated for FACS, IF (cc) and IF (p). It is suitable to detect ABCA7 in samples from Human.

Quick Overview for ABCA7 antibody (AA 251-350) (AbBy Fluor® 750) (ABIN4995862)

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA7 antibody is conjugated to AbBy Fluor® 750

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ABCA7 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 251-350

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ABCA7

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ABCA7

Target: ABCA7 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 7 (ABCA7))

Alternative Name: ABCA7

Background:

Synonyms: ABC transporter ABCA7, ABC transporter member 7, ABCA SSN, ABCX, ATP binding cassette sub family A ABC1 member 7, ATP binding cassette sub family A member 7, ATP binding Cassette Transporter A7,FLJ40025, Macrophage ABC transporter, ABCA7_HUMAN.

Background: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of widely-expressed proteins that use ATP hydrolysis to catalyze the transport of various molecules across extracellular and intracellular membranes. Eukaryotic ABC transporters are largely responsible for trafficking hydrophobic compounds either within the cell as part of a metabolic process, outside the cell for transport to other organs, or for secretion from the body. The cholesterol-responsive transporter, ABCA7, maps to human chromosome 19 and mouse chromosome 10 and has been reported as a candidate regulator of ceramide transport in epidermal lipid reorganization. High expression levels of ABCA7 have been reported in myelolymphatic tissues, reticuloendothelial cells, peripheral leukocytes, thymus, spleen and bone marrow. This expression pattern of the two alternatively-spliced isoforms also indicates an involvement in lipid homeostasis in cells of the immune system, though the complete role of ABCA7 is not yet known. Full-length type I ABCA7 has shown plasma membrane localization, while the type II splicing variant has shown expression predominantly in the endoplasmic reticulum.