FAIM antibody (C-Term)

Catalog No. ABIN499820

The Rabbit Polyclonal anti-FAIM antibody has been validated for WB and EIA. It is suitable to detect FAIM in samples from Human and Mouse.

Quick Overview for FAIM antibody (C-Term) (ABIN499820)

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FAIM Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to FAIM.

Purification: Affinity chromatography purified via peptide column

Immunogen: FAIM antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human FAIM.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for FAIM

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Alternative Name: FAIM

Background: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappaB and the Ras-ERK pathway.Synonyms: FAIM-1, FAIM1, Fas Apoptotic Inhibitory Molecule 1

Gene ID: 55179

NCBI Accession: NP_060617

UniProt: Q9NVQ4