CLEC12A antibody (AA 61-160) (AbBy Fluor® 680)

Catalog No. ABIN5000185

The Rabbit Polyclonal anti-CLEC12A antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect CLEC12A in samples from Human.

Quick Overview for CLEC12A antibody (AA 61-160) (AbBy Fluor® 680) (ABIN5000185)

Target: CLEC12A (C-Type Lectin Domain Family 12, Member A (CLEC12A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLEC12A antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CLEC12A Antibody (AbBy Fluor® 680)

Binding Specificity: AA 61-160

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLEC12A

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLEC12A

Target: CLEC12A (C-Type Lectin Domain Family 12, Member A (CLEC12A))

Alternative Name: CLEC12A

Background:

Synonyms: C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CL12A_HUMAN, CLEC12A, CLL-1, DCAL-2, Dendritic cell-associated lectin 2, MICL, Myeloid inhibitory C-type lectin-like receptor.

Background: The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-12A (C-type lectin domain family 12, member A), also known as CLL1, MICL, CLL-1 or DCAL-2, is a 275 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Existing as multiple alternatively spliced isoforms that are expressed in neutrophils, eosinophils, monocytes and dendritic cells, CLEC-12A functions as a cell surface receptor that acts as a negative regulator of granulocyte and monocyte function and, via this activity, modulates signaling cascades. CLEC-12A is highly subject to post-translational glycosylation at its N-terminus and may also exist as a homodimer.