LGI2 antibody (Center)

Catalog No. ABIN500156

The Rabbit Polyclonal anti-LGI2 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect LGI2 in samples from Human and Mouse.

Quick Overview for LGI2 antibody (Center) (ABIN500156)

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-LGI2 Antibody

Binding Specificity: Center

Specificity: This antibody detetcs LGI2 at center. It will recognize only the longest isoform. The antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: LGI2 antibody was raised against a 10 amino acid peptide from near the center of human LGI2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for LGI2

Target: LGI2 (Leucine-Rich Repeat LGI Family, Member 2 (LGI2))

Alternative Name: LGI2

Background: The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE. Three isoforms of LGI2 are known to exist.Synonyms: KIAA1916, LGI1-like protein 2, LGI2, LGIL2, Leucine-rich glioma-inactivated protein 2, Leucine-rich repeat LGI family member 2

Gene ID: 55203

NCBI Accession: NP_060646

UniProt: Q8N0V4