TP53INP1 antibody (N-Term)

Catalog No. ABIN500435

The Rabbit Polyclonal anti-TP53INP1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect TP53INP1 in samples from Human, Mouse and Rat. There is 1 publication available.

Quick Overview for TP53INP1 antibody (N-Term) (ABIN500435)

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53INP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TP53INP1 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects TP53INP1.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Peptide Affinity Chromatography

Immunogen: A synthetic peptide corresponding to 14 amino acids near the amino terminus of Human p53DINP1. .Remarks: This sequence is identical between apha and beta forms of the p53DINP1 proteins, and differs by one amino acid from those of Mouse.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot (1-2 μg/mL). Human lung tissue lysate can be used as a Positive Control and a band at 27 kDa can bedetected. A lower band at 18 kDa was detected in Human spleen, and Mouse liver andkidney tissue lysates, which may represent the p53DINP1-beta form. Immunohistochemistry on Paraffin Sections (2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

References for anti-TP53INP1 antibody (ABIN500435)

Ferrajoli, Ivan, Ciccone, Shimizu, Kita, Ohtsuka, DAbundo, Qiang, Lerner, Nouraee, Rabe, Rassenti, Van Roosbroeck, Manning, Yuan, Zhang, Shanafelt, Wierda, Sabbioni, Tarrand, Estrov, Radovich, Liang et al.: "Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. ..." in: EBioMedicine, Vol. 2, Issue 6, pp. 572-82, (2016) (PubMed).

Target Details for TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Alternative Name: TP53INP1

Background: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2).?A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-a and p53DINP1-b or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).Synonyms: P53DINP1, SIP, Stress-induced protein, Tumor protein p53-inducible nuclear protein 1, p53-dependent damage-inducible nuclear protein 1, p53-inducible nuclear protein 1

Gene ID: 94241

UniProt: Q96A56