CBX5 antibody (pTyr43) (AbBy Fluor® 750)

Catalog No. ABIN5004829

The Rabbit Polyclonal anti-CBX5 antibody has been validated for WB, IF (p) and IF (cc). It is suitable to detect CBX5 in samples from Others.

Quick Overview for CBX5 antibody (pTyr43) (AbBy Fluor® 750) (ABIN5004829)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Reactivity: Others

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX5 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-CBX5 Antibody (AbBy Fluor® 750)

Binding Specificity: pTyr43

Cross-Reactivity (Details): Fruit Fly

Predicted Reactivity: Drosophila

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from Drosophila Melanogaster HP1 around the phosphorylation site of Tyr43

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Alternative Name: HP1

Background:

Synonyms: Heterochromatin protein 1, HP1, Non-histone chromosomal protein C1A9 antigen, CG8409

Background: HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.

Gene ID: 34119