NEUROD2 antibody (AA 121-250) (AbBy Fluor® 750)

Catalog No. ABIN5007466

The Rabbit Polyclonal anti-NEUROD2 antibody has been validated for WB, IF (cc), IF (p). It is suitable to detect NEUROD2 in samples from Human.

Quick Overview for NEUROD2 antibody (AA 121-250) (AbBy Fluor® 750) (ABIN5007466)

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEUROD2 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-NEUROD2 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 121-250

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neuro D2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NEUROD2

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Alternative Name: Neuro D2

Background:

Synonyms: bHLHa1, Class A basic helix-loop-helix protein 1, class A basic helix loop helix protein 1, NDF2_HUMAN, NDR2, NDRF, Neuro-D2, NeuroD-related factor, NeuroD2, Neurogenic dferentiation factor 2, NDF2_HUMAN, neuroD related factor, NeuroD2, neurogenic basic helix loop helix protein, neurogenic dferentiation 2, Neurogenic dferentiation factor 2, neuronal dferentiation 2.

Background: Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix (bHLH) transcription factors that function as dominant negative regulators and are involved in cell lineage determination and differentiation. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.