CYLD antibody (AA 1-230)

Catalog No. ABIN5027126

This anti-CYLD antibody is a Rabbit Polyclonal antibody detecting CYLD in WB. Suitable for Human.

Quick Overview for CYLD antibody (AA 1-230) (ABIN5027126)

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYLD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYLD Antibody

Binding Specificity: AA 1-230

Purification: Protein A Chromatography

Immunogen: A partial length recombinant CYLD protein (amino acids 1-230 ) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Alternative Name: CYLD

Background: CYLD (Ubiquitin carboxyl-terminal hydrolase) belongs to peptidase C19 family with 956 amino acids. It is a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains which function as a deubiquitinating enzyme which specifically cleaves 'Lys-63'-linked polyubiquitin chains and 1 ubiquitin-specific proteases (USP) domain. CYLD plays an important role in the regulation of pathways leading to NF-kappa-B activation, proliferation and differentiation. It also interacts with (via CAP-Gly domain) IKBKG/NEMO (via proline-rich C-terminal region). CYLD is important for the survival of immature natural killer cells whereas it is not required for the maturation of intrathymic natural killer cells. It is detected in fetal brain, testis and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. CYLD related diseases are multiple familial trichoepithelioma 1 and familial cylindromatosis.

Molecular Weight: 105 kDa

Gene ID: 1540

UniProt: Q9NQC7

Pathways: Apoptosis, Activation of Innate immune Response