DEPTOR antibody (AA 111-301)

Catalog No. ABIN5027150

The Rabbit Polyclonal anti-DEPTOR antibody (ABIN5027150) specifically detects DEPTOR in WB. The antibody is reactive with Human samples.

Quick Overview for DEPTOR antibody (AA 111-301) (ABIN5027150)

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEPTOR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DEPTOR Antibody

Binding Specificity: AA 111-301

Purification: Protein A Chromatography

Immunogen: A partial length recombinant DEPTOR protein (amino acids 111-301) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for DEPTOR

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Alternative Name: DEPTOR/DEPDC6

Background: DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. DEPTOR is expressed in different microvascular ECs (endothelial cells). It plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs). It is overexpressed in RPMI-8226 human multiple myeloma cells, and plays an important role in maintaining cell survival.

Molecular Weight: 46 kDa

Gene ID: 64798

UniProt: Q8TB45

Pathways: PI3K-Akt Signaling, RTK Signaling, Regulation of Cell Size, BCR Signaling, Warburg Effect