AADAC antibody (AA 201-300)

Catalog No. ABIN513029

The Mouse Monoclonal anti-AADAC antibody has been validated for WB and ELISA. It is suitable to detect AADAC in samples from Human. There are 5+ publications available.

Quick Overview for AADAC antibody (AA 201-300) (ABIN513029)

Target: AADAC (Arylacetamide Deacetylase (Esterase) (AADAC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AADAC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2E8

Product Details anti-AADAC Antibody

Binding Specificity: AA 201-300

Purpose: Mouse monoclonal antibody raised against a partial recombinant AADAC.

Sequence: QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF INWSSLLPER FIKGHVYNNP

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: AADAC (NP_001077, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AADAC antibody (ABIN513029)

Muta, Fukami, Nakajima, Yokoi: "N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity." in: Biochemical pharmacology, Vol. 87, Issue 2, pp. 352-9, (2014) (PubMed).

Kobayashi, Fukami, Nakajima, Watanabe, Nakajima, Yokoi: "Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 4, pp. 671-9, (2012) (PubMed).

Shimizu, Fukami, Kobayashi, Takamiya, Aoki, Nakajima, Yokoi: "A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 6, pp. 1183-90, (2012) (PubMed).

Kobayashi, Fukami, Higuchi, Nakajima, Yokoi: "Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia." in: Biochemical pharmacology, Vol. 84, Issue 9, pp. 1196-206, (2012) (PubMed).

Watanabe, Fukami, Nakajima, Takamiya, Aoki, Yokoi: "Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 37, Issue 7, pp. 1513-20, (2009) (PubMed).

Target Details for AADAC

Target: AADAC (Arylacetamide Deacetylase (Esterase) (AADAC))

Alternative Name: AADAC

Background: Full Gene Name: arylacetamide deacetylase (esterase)
Synonyms: CES5A1,DAC

Gene ID: 13

NCBI Accession: NM_001086