ATP6V1A antibody (AA 508-617)

Catalog No. ABIN513625

Product Details anti-ATP6V1A Antibody

Target: ATP6V1A (ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A))

Binding Specificity: AA 508-617

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This ATP6V1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse polyclonal antibody raised against a partial recombinant ATP6V1A.

Sequence: TLEVAKLIKD DFLQQNGYTP YDRFCPFYKT VGMLSNMIAF YDMARRAVET TAQSDNKITW SIIREHMGDI LYKLSSMKFK DPLKDGEAKI KSDYAQLLED MQNAFRSLED

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: ATP6V1A (NP_001681, 508 a.a. ~ 617 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-ATP6V1A antibody (ABIN513625)

Liberman, Bond, Shainheit, Stadecker, Forgac: "Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway." in: The Journal of biological chemistry, Vol. 289, Issue 3, pp. 1355-63, (2014) (PubMed).

Matsuda, Okada, Kodama, Honda, Iida: "A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes." in: PLoS pathogens, Vol. 8, Issue 7, pp. e1002803, (2012) (PubMed).

Huang, Chen, Shen, Shen, Guo, Gao, Zou: "Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells." in: Cancer letters, Vol. 315, Issue 2, pp. 198-205, (2011) (PubMed).

Chen, Zou, Luo, Cao, Zhang, Zhang, Liu: "Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells." in: Cell biology international, Vol. 33, Issue 9, pp. 1008-19, (2009) (PubMed).

Target Details for ATP6V1A

Target: ATP6V1A (ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A))

Alternative Name: ATP6V1A (ATP6V1A Products)

Background: Full Gene Name: ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A
Synonyms: ATP6A1,ATP6V1A1,HO68,VA68,VPP2,Vma1

Gene ID: 523

NCBI Accession: NM_001690

Pathways: Transition Metal Ion Homeostasis, Proton Transport, SARS-CoV-2 Protein Interactome