AKR1C1 antibody (AA 1-323)

Catalog No. ABIN514921

This Mouse Polyclonal antibody specifically detects AKR1C1 in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for AKR1C1 antibody (AA 1-323) (ABIN514921)

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This AKR1C1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AKR1C1 Antibody

Binding Specificity: AA 1-323

Purpose: Mouse polyclonal antibody raised against a full-length human AKR1C1 protein.

Sequence: MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: AKR1C1 (NP_001344.2, 1 a.a. ~ 323 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AKR1C1 antibody (ABIN514921)

Han, Bourboulia, Jensen-Taubman, Isaac, Wei, Stetler-Stevenson: "An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells." in: Oncogene, Vol. 33, Issue 9, pp. 1198-206, (2014) (PubMed).

Choi, Ryoo, Kang, Kwak: "The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing." in: PLoS ONE, Vol. 9, Issue 9, pp. e107158, (2014) (PubMed).

Ebert, Kisiela, Wsól, Maser: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).

Target Details for AKR1C1

Target: AKR1C1 (DDH) (Dihydrodiol Dehydrogenase (DDH))

Alternative Name: AKR1C1

Background: Full Gene Name: aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
Synonyms: 2-ALPHA-HSD,20-ALPHA-HSD,C9,DD1,DDH,DDH1,H-37,HAKRC,MBAB,MGC8954

Gene ID: 1645

NCBI Accession: NM_001353

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process