KLC1 antibody (C-Term)

Catalog No. ABIN5514913

The Rabbit Polyclonal anti-KLC1 antibody has been validated for WB. It is suitable to detect KLC1 in samples from Human.

Quick Overview for KLC1 antibody (C-Term) (ABIN5514913)

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KLC1 Antibody

Binding Specificity: C-Term

Sequence: ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGTSFGEYG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KLC1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KLC1

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Alternative Name: KLC1

Background: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos, however, the full-length nature and/or biological validity of most of these variants have not been determined.

Alias Symbols: KLC, KNS2, KNS2A,

Protein Interaction Partner: CCDC114, KRT31, BNIP2, UBC, EZH2, TLE3, KIF5B, DIAPH1, COPB1, ARCN1, KLC4, KLC2, SMEK2, PTPN23, COPZ1, APP, RIC3, BSDC1, FAM63B, PRKAG3, LDLRAP1, RASSF8, YWHAE, SKP1, SNCA, KIF5A, MAPK6, YWHAB, LRSAM1, MAPK8IP3, PLEKHM2, CLSTN1, SPAG9, MAPK8IP2, MAPK8IP1,

Protein Size: 551

Gene ID: 3831

NCBI Accession: NM_001130107, NP_005543

Pathways: Ribonucleoprotein Complex Subunit Organization