CD70 antibody (C-Term)

Catalog No. ABIN5516679

This Rabbit Polyclonal antibody specifically detects CD70 in WB. It exhibits reactivity toward Human, Mouse, Cow, Rabbit, Horse, Rat, Pig and Dog.

Quick Overview for CD70 antibody (C-Term) (ABIN5516679)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human, Mouse, Cow, Rabbit, Horse, Rat, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD70 Antibody

Binding Specificity: C-Term

Sequence: RLSFHQGCTI ASQRLTPLAR GDTLCTNLTG TLLPSRNTDE TFFGVQWVRP

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 92%, Rabbit: 79%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against CD70. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CD70

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Alias Symbols: CD27L, CD27LG, TNFSF7

Protein Interaction Partner: UBC, CD27, ELAVL1,

Protein Size: 193

Gene ID: 970

NCBI Accession: NP_001243

UniProt: P32970

Pathways: Cancer Immune Checkpoints