LMO1 antibody (C-Term)

Catalog No. ABIN5518772

This anti-LMO1 antibody is a Rabbit Polyclonal antibody detecting LMO1 in WB. Suitable for Human, Rat and Mouse.

Quick Overview for LMO1 antibody (C-Term) (ABIN5518772)

Target: LMO1 (LIM Domain Only 1 (Rhombotin 1) (LMO1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LMO1 Antibody

Binding Specificity: AA 127-156, C-Term

Purpose: Anti-LMO1 Antibody Picoband®

Sequence: DKFFLKNNMI LCQMDYEEGQ LNGTFESQVQ

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-LMO1 Antibody Picoband® (ABIN5518772). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LMO1, different from the related mouse sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)". 2. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367-71. 3. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599-606.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for LMO1

Target: LMO1 (LIM Domain Only 1 (Rhombotin 1) (LMO1))

Alternative Name: LMO1

Background:

Synonyms: Rhombotin-1,Cysteine-rich protein TTG-1,LIM domain only protein 1,LMO-1,T-cell translocation protein 1,LMO1,RBTN1, RHOM1, TTG1,

Tissue Specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. .

Background: Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene. This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions, thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.

Molecular Weight: 18 kDa

Gene ID: 4004

UniProt: P25800

Pathways: Dopaminergic Neurogenesis