PLAUR antibody (AA 230-286)

Catalog No. ABIN5518863

This Rabbit Polyclonal antibody specifically detects PLAUR in WB. It exhibits reactivity toward Human.

Quick Overview for PLAUR antibody (AA 230-286) (ABIN5518863)

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAUR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAUR Antibody

Binding Specificity: AA 230-286

Purpose: Anti-uPA Receptor/PLAUR Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-uPA Receptor/PLAUR Antibody Picoband® (ABIN5518863). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PLAUR recombinant protein (Position: E230-S286). Human PLAUR shares 63.2% amino acid (aa) sequence identity with both mouse and rat PLAUR.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Borglum, A., Anette, B., Roldan, A. L., Blasi, F., Bolund, L., Kruse, T. A. Assignment of the gene for urokinase-type plasminogen activator receptor to chromosome 19q13. 2. Borglum, A. D., Byskov, A., Ragno, P., Roldan, A. L., Tripputi, P., Cassani, G., Dano, K., Blasi, F., Bolund, L., Kruse, T. A. Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19q13.1-q13.2. Am. J. Hum. Genet. 50: 492-497, 1992. 3. Llinas P, Le Du MH, Gårdsvoll H, et al. (May 2005). "Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide".

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for PLAUR

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Alternative Name: PLAUR

Background:

Synonyms: Urokinase plasminogen activator surface receptor,U-PAR,uPAR,Monocyte activation antigen Mo3,CD87,PLAUR,MO3, UPAR,

Tissue Specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Background: PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

Molecular Weight: 39 kDa, 55 kDa

Gene ID: 5329

UniProt: Q03405

Pathways: Inositol Metabolic Process