FOXP2 antibody (AA 637-715)

Catalog No. ABIN5518915

The Rabbit Polyclonal anti-FOXP2 antibody has been validated for WB. It is suitable to detect FOXP2 in samples from Human, Mouse and Rat.

Quick Overview for FOXP2 antibody (AA 637-715) (ABIN5518915)

Target: FOXP2 (Forkhead Box P2 (FOXP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FOXP2 Antibody

Binding Specificity: AA 637-715

Purpose: Anti-FOXP2 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FOXP2 Antibody Picoband® (ABIN5518915). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human FOXP2 recombinant protein (Position: L637-E715). Human FOXP2 shares 100% amino acid (aa) sequence identity with both mouse and rat FOXP2.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Bruce, H. A., Margolis, R. L. FOXP2: novel exons, splice variants, and CAG repeat length stability. Hum. Genet. 111: 136-144, 2002. 2. Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Monaco, A. P., Paabo, S. Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418: 869-872, 2002. 3. Haesler, S., Wada, K., Nshdejan, A., Morrisey, E. E., Lints, T., Jarvis, E. D., Scharff, C. FoxP2expression in avian vocal learners and non-learners. J. Neurosci. 24: 3164-3175, 2004.

Comment:

We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FOXP2

Target: FOXP2 (Forkhead Box P2 (FOXP2))

Alternative Name: FOXP2

Background:

Synonyms: Forkhead box protein P2,CAG repeat protein 44,Trinucleotide repeat-containing gene 10 protein,FOXP2,CAGH44, TNRC10,

Tissue Specificity: Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. .

Background: Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind ly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia.

Molecular Weight: 90 kDa

Gene ID: 93986

UniProt: O15409