ING4 antibody (C-Term)

Catalog No. ABIN5531436

The Rabbit Polyclonal anti-ING4 antibody has been validated for WB and IHC (p). It is suitable to detect ING4 in samples from Human.

Quick Overview for ING4 antibody (C-Term) (ABIN5531436)

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ING4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ING4 Antibody

Binding Specificity: AA 162-195, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

Isotype: Ig Fraction

Application Details

Application Notes: For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ING4

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Alternative Name: ING4

Background: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Molecular Weight: 29 kDa

Gene ID: 51147

UniProt: Q9UNL4