Aminoacylase 1 antibody (AA 1-408)

Catalog No. ABIN5539999

This anti-Aminoacylase 1 antibody is a Mouse Monoclonal antibody detecting Aminoacylase 1 in WB and EIA. Suitable for Human.

Quick Overview for Aminoacylase 1 antibody (AA 1-408) (ABIN5539999)

Target: Aminoacylase 1 (ACY1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Aminoacylase 1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT1E2

Product Details anti-Aminoacylase 1 Antibody

Binding Specificity: AA 1-408

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human ACY1 (1-408aa) purified from E. coli.

Isotype: IgG2b

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Aminoacylase 1

Target: Aminoacylase 1 (ACY1)

Alternative Name: aminoacylase-1,acy1

Background: Aminoacylase-1, also designated N-acyl-L-amino-acid amidohydrolase or ACY1, is a member of the largest metallopeptidase family called M20A. Aminoacylase-1 is a zinc-binding homodimeric enzyme expressed in kidney, brain, placenta and spleen. It is the most abundant of the aminoacylases. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.

UniProt: Q03154