CDNF antibody

Catalog No. ABIN5540986

This anti-CDNF antibody is a Mouse Monoclonal antibody detecting CDNF in WB, ICC, IHC (p), IF and EIA. Suitable for Human.

Quick Overview for CDNF antibody (ABIN5540986)

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDNF antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: 7G5

Product Details anti-CDNF Antibody

Specificity: Recognizes Human CDNF and not Mouse CDNF. Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogen: Recombinant Human CDNF produced using CHO-based. Antigen is purified from cell culture supernatant.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/5000-1/10000. Western Blot: 1/1000-1/4000. Immunofluorescence: 1/100-1/300. Immunohistochemistry on Paraffin Sections: 1/100-1/200. Formalin-fixed, paraffin-embedded tissues requires antigen retrieval.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.4 Preservatives: 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CDNF

Target: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Alternative Name: cdnf

Background: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007 Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson's disease. When administered after 6-OHDA or MPTP -lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.

UniProt: Q49AH0