CCR4 antibody

Catalog No. ABIN5541087

The Mouse Monoclonal anti-CCR4 antibody has been validated for FACS, IF, ICC and EIA. It is suitable to detect CCR4 in samples from Human.

Quick Overview for CCR4 antibody (ABIN5541087)

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

Clone: KH-4F5

Product Details anti-CCR4 Antibody

Specificity: Recognizes Human CCR4. Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogen: Immunisation with Human CCR4 peptide.

Isotype: IgG2a

Application Details

Application Notes: Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 μg/10 6 cells. Immunofluorescence: 1 μg/10

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Alternative Name: cd194,ccr4

Background: CCR4 (CC chemokine receptor 4) belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane-bound molecules composed of 7-transmembrane domains and are coupled to G-proteins (1,2). CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4(+) thymocytes especially in TH2- and regulatory T-cells (3,4). It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways (2,5).

UniProt: P51679