ICOSLG antibody (Extracellular Domain)

Catalog No. ABIN5541150

The Mouse Monoclonal anti-ICOSLG antibody has been validated for FACS and EIA. It is suitable to detect ICOSLG in samples from Human.

Quick Overview for ICOSLG antibody (Extracellular Domain) (ABIN5541150)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICOSLG antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: GM13C1

Product Details anti-ICOSLG Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody recognizes Human CD275 / ICOS Ligand. Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogen: Genetic immunisation with cDNA encoding Human ICOSL (Extracellular Domain).

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Alternative Name: cd275,icos ligand

Background: Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS)(1). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secre-tion (2,3).

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation