ACVR1 antibody (AA 21-120)

Catalog No. ABIN5542584

Product Details anti-ACVR1 Antibody

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACVR1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: ACVR1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. Coli.

Clone: 2C1E8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for ACVR1

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Alternative Name: ACVR1 (ACRV1 Products)

Background:

Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Aliases: FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2

Molecular Weight: 57.2kDa

Gene ID: 90

HGNC: 6850

UniProt: Q04771