GAD65 antibody (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa)) (AA 1-100)

Catalog No. ABIN5542620

Product Details anti-GAD65 Antibody

Target:

GAD65 (GAD2)

Binding Specificity: AA 1-100

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GAD65 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)

Immunogen: Purified recombinant fragment of human GAD2 (AA 1-100) expressed in E. Coli.

Clone: 5D9G12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: , FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.05 % sodium azide

Storage: 4 °C,-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for GAD65

Target:

GAD65 (GAD2)

Alternative Name: GAD2 (GAD2 Antibody Abstract)

Synonyms: GAD65, gad65, F12P19.12, F12P19_12, GLUTAMATE DECARBOXYLASE 2, glutamate decarboxylase 2, zgc:112198, 6330404F12Rik, GAD(65), Gad-2, glutamate decarboxylase 2, glutamate decarboxylase 1, glutamic acid decarboxylase 2, GAD2, PTRG_06148, LOC9324534, Gad2, GAD1, gad2

Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.,

Molecular Weight: 65.4kDa

HGNC: 2572