BCL2L1 antibody

Catalog No. ABIN5557286

This anti-BCL2L1 antibody is a Rabbit Monoclonal antibody detecting BCL2L1 in WB, IHC (p) and IF (cc). Suitable for Human.

Quick Overview for BCL2L1 antibody (ABIN5557286)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCL2L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 12C5

Product Details anti-BCL2L1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant human Bcl-XL protein, around 1-100aa.

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Alternative Name: Bcl-XL

Background:

Synonyms: BCL2L1 phospho T47, BCL2L1 phospho Thr47, p-BCL2L1 phospho T47, p-BCL2L1 Thr47, p-BCL2L1Thr115, Apoptosis regulator Bcl X, BclX, Bcl-X, Bcl 2 like 1, Bcl 2 like 1 protein, Bcl xL, BCL X/L, BCL XL/S, Bcl xS, Bcl2 like1, BCL2-related gene, BCL2-related protein, long isoform, included, BCLXL, included, BCL2-related protein, short isoform, included, BCLXS, included, BCL2L, BCL2L1, Bclx, DKFZp781P2092, MGC113803, MGC99998, B2CL1_HUMAN.

Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Gene ID: 598

UniProt: Q07817

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling