BRP44 antibody

Catalog No. ABIN5564218

This anti-BRP44 antibody is a Mouse Monoclonal antibody detecting BRP44 in WB and IP. Suitable for Human and Mouse.

Quick Overview for BRP44 antibody (ABIN5564218)

Target: BRP44 (Brain Protein 44 (BRP44))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This BRP44 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: JCM-1

Product Details anti-BRP44 Antibody

Specificity: Recognizes endogenous human and mouse MPC-2.

Cross-Reactivity: Human, Mouse (Murine)

Immunogen: Peptide coupled to KLH.

Isotype: IgG2b

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 25 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for BRP44

Target: BRP44 (Brain Protein 44 (BRP44))

Alternative Name: MPC-2

Background: Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Two proteins, mitochondrial pyruvate carriers MPC-1 and MPC-2, form a heterooligomeric complex in the IMM to facilitate pyruvate transport. This step is required for mitochondrial pyruvate oxidation and carboxylation-critical reactions in intermediary metabolism that are dysregulated in several common metabolic diseases.

Pathways: Warburg Effect