Recombinant CD40L (Ruplizumab Biosimilar) antibody

Catalog No. ABIN5564228

This Human Monoclonal antibody specifically detects CD40L (Ruplizumab Biosimilar) in FACS, WB and Func. It exhibits reactivity toward Human and Dog.

Quick Overview for Recombinant CD40L (Ruplizumab Biosimilar) antibody (ABIN5564228)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Antibody Type: Recombinant Antibody

Reactivity: Human, Dog

Host: Human

Clonality: Monoclonal

Conjugate: This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)

Clone: Hu5c8

Product Details anti-CD40L (Ruplizumab Biosimilar) Antibody

Specificity: Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.

Cross-Reactivity: Dog (Canine), Human

Cross-Reactivity (Details): Cross-reacts with canine CD40L.

Purity: >95 % (SDS-PAGE)

Endotoxin Level: <0.001EU/μg

Immunogen: Recombinant human CD40L.

Isotype: IgG1

Application Details

Comment:

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

Expiry Date: 12 months

Target Details for CD40L (Ruplizumab Biosimilar)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Alternative Name: CD40L (Ruplizumab Biosimilar)

Target Type: Biosimilar

Background: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

UniProt: P29965