LETM1 antibody (AA 601-708)

Catalog No. ABIN561659

The Mouse Monoclonal anti-LETM1 antibody has been validated for WB, ELISA, IF, IP and IHC (p). It is suitable to detect LETM1 in samples from Human. There are 6+ publications available.

Quick Overview for LETM1 antibody (AA 601-708) (ABIN561659)

Target: LETM1 (Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LETM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6F7

Product Details anti-LETM1 Antibody

Binding Specificity: AA 601-708

Purpose: Mouse monoclonal antibody raised against a partial recombinant LETM1.

Sequence: ESKASKRLTK RVQQMIGQID GLISQLEMDQ QAGKLAPANG MPTGENVISV AELINAMKQV KHIPESKLTS LAAALDENKD GKVNIDDLVK VIELVDKEDV HISTSQVA

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: LETM1 (NP_036450, 601 a.a. ~ 708 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-LETM1 antibody (ABIN561659)

Chen, Yang, Liu, Piao, Zhang, Lin, Li: "High expression of leucine zipper-EF-hand containing transmembrane protein 1 predicts poor prognosis in head and neck squamous cell carcinoma." in: BioMed research international, Vol. 2014, pp. 850316, (2014) (PubMed).

Doonan, Chandramoorthy, Hoffman, Zhang, Cárdenas, Shanmughapriya, Rajan, Vallem, Chen, Foskett, Cheung, Houser, Madesh: "LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4936-49, (2014) (PubMed).

Shin, Chung, Kang, Jiang, Yu, Han, Chae, Moon, Jang, Cho: "Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice." in: Cancer gene therapy, Vol. 20, Issue 3, pp. 186-94, (2013) (PubMed).

Piao, Li, Kim, Sohn, Yang, Park, Byun, Won, Hong, Hur, Seok, Shong, Sack, Brazil, Hemmings, Park: "Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis." in: Cellular signalling, Vol. 21, Issue 5, pp. 767-77, (2009) (PubMed).

Piao, Li, Kim, Byun, Huang, Hwang, Yang, Park, Won, Hong, Hur, Seok, Shong, Cho, Brazil, Hemmings, Park: "Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death." in: Cancer research, Vol. 69, Issue 8, pp. 3397-404, (2009) (PubMed).

Dimmer, Navoni, Casarin, Trevisson, Endele, Winterpacht, Salviati, Scorrano: "LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability." in: Human molecular genetics, Vol. 17, Issue 2, pp. 201-14, (2008) (PubMed).

Target Details for LETM1

Target: LETM1 (Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1))

Alternative Name: LETM1

Background: Full Gene Name: leucine zipper-EF-hand containing transmembrane protein 1
Synonyms:

Gene ID: 3954

NCBI Accession: NM_012318