AGR2 antibody (AA 1-175)

Catalog No. ABIN564604

This Mouse Monoclonal antibody specifically detects AGR2 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 9+ publications.

Quick Overview for AGR2 antibody (AA 1-175) (ABIN564604)

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AGR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1C3

Product Details anti-AGR2 Antibody

Binding Specificity: AA 1-175

Purpose: Mouse monoclonal antibody raised against a full length recombinant AGR2.

Sequence: MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTEL

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: AGR2 (AAH15503.1, 1 a.a. ~ 175 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AGR2 antibody (ABIN564604)

Dong, Wodziak, Lowe: "Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface." in: The Journal of biological chemistry, Vol. 290, Issue 13, pp. 8016-27, (2015) (PubMed).

Riener, Thiesler, Hellerbrand, Amann, Cathomas, Fritzsche, Dahl, Bahra, Weichert, Terracciano, Kristiansen: "Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas." in: European journal of cancer (Oxford, England : 1990), Vol. 50, Issue 10, pp. 1722-30, (2014) (PubMed).

Gray, Murray, Nowicki, Remnant, Scherl, Muller, Vojtesek, Hupp: "Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein." in: Protein science : a publication of the Protein Society, Vol. 22, Issue 9, pp. 1266-78, (2013) (PubMed).

Wayner, Quek, Ahmad, Ho, Loprieno, Zhou, Ellis, True, Liu: "Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine." in: The Prostate, Vol. 72, Issue 9, pp. 1023-34, (2012) (PubMed).

Darb-Esfahani, Fritzsche, Kristiansen, Weichert, Sehouli, Braicu, Dietel, Denkert: "Anterior gradient protein 2 (AGR2) is an independent prognostic factor in ovarian high-grade serous carcinoma." in: Virchows Archiv : an international journal of pathology, Vol. 461, Issue 2, pp. 109-16, (2012) (PubMed).

Lepreux, Bioulac-Sage, Chevet: "Differential expression of the anterior gradient protein-2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 31, Issue 3, pp. 322-8, (2011) (PubMed).

Ambolet-Camoit, Bui, Pierre, Chevallier, Marchand, Coumoul, Garlatti, Andreau, Barouki, Aggerbeck: "2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 2, pp. 501-12, (2010) (PubMed).

Maslon, Hrstka, Vojtesek, Hupp: "A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin." in: Journal of molecular biology, Vol. 404, Issue 3, pp. 418-38, (2010) (PubMed).

Zhao, Lee, Brown, Molloy, Marx, Pavlakis, Boyer, Stockler, Kaplan, Breit, Sutherland, Henshall, Horvath: "Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling." in: Cancer research, Vol. 69, Issue 19, pp. 7696-703, (2009) (PubMed).

Target Details for AGR2

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Alternative Name: AGR2

Background: Full Gene Name: anterior gradient homolog 2 (Xenopus laevis)
Synonyms: AG2,GOB-4,HAG-2,XAG-2

Gene ID: 10551