PD-L1 antibody (AA 41-69)

Catalog No. ABIN5647488

This Rabbit Polyclonal antibody specifically detects PD-L1 in WB. It exhibits reactivity toward Human.

Quick Overview for PD-L1 antibody (AA 41-69) (ABIN5647488)

Target: PD-L1 (CD274 (PD-L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PD-L1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PD-L1 Antibody

Binding Specificity: AA 41-69

Purification: Antigen affinity purified

Immunogen: Amino acids 41-69 (KFPVEKQLDLAALIVYWEMEDKNIIQFVH-human) were used as the immunogen for the B7-H1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the B7-H1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the B7-H1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for PD-L1

Target: PD-L1 (CD274 (PD-L1))

Alternative Name: PD-L1 / B7-H1 / CD274

Background: B7 Homolog 1 (B7-H1), also known as CD274 or PD-L1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. B7-H1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of B7-H1 on tumor MDCs downregulates T-cell immunity and that B7-H1 blockade may represent an approach for cancer immunotherapy. Additionally, B7-H1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection.

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints