Coronin 1a antibody (AA 360-461)

Catalog No. ABIN564843

Product Details anti-Coronin 1a Antibody

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Binding Specificity: AA 360-461

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Coronin 1a antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a partial recombinant CORO1A.

Sequence: QEDLYPPTAG PDPALTAEEW LGGRDAGPLL ISLKDGYVPP KSRELRVNRG LDTGRRRAAP EASGTPSSDA VSRLEEEMRK LQATVQELQK RLDRLEETVQ AK

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CORO1A (NP_009005, 360 a.a. ~ 461 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 4G10

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Coronin 1a antibody (ABIN564843)

Jayachandran, Liu, Bosedasgupta, Müller, Zhang, Moshous, Studer, Schneider, Genoud, Fossoud, Gambino, Khelfaoui, Müller, Bartholdi, Rossez, Stiess, Houbaert, Jaussi, Frey, Kammerer, Deupi et al.: "Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling. ..." in: PLoS biology, Vol. 12, Issue 3, pp. e1001820, (2014) (PubMed).

Federzoni, Humbert, Valk, Behre, Leibundgut, Torbett, Fey, Tschan: "The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients." in: British journal of haematology, Vol. 160, Issue 6, pp. 855-9, (2013) (PubMed).

Moriceau, Kantari, Mocek, Davezac, Gabillet, Guerrera, Brouillard, Tondelier, Sermet-Gaudelus, Danel, Lenoir, Daniel, Edelman, Witko-Sarsat: "Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 7254-63, (2009) (PubMed).

Target Details for Coronin 1a

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Alternative Name: CORO1A (CORO1A Products)

Background: Full Gene Name: coronin, actin binding protein, 1A
Synonyms: CLABP,CLIPINA,FLJ41407,HCORO1,MGC117380,TACO,p57

Gene ID: 11151

NCBI Accession: NM_007074

Pathways: Regulation of Actin Filament Polymerization