AKR1B10 antibody (AA 76-143)

Catalog No. ABIN566074

This Mouse Monoclonal antibody specifically detects AKR1B10 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human and has been mentioned in 8+ publications.

Quick Overview for AKR1B10 antibody (AA 76-143) (ABIN566074)

Target: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AKR1B10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1A6

Product Details anti-AKR1B10 Antibody

Binding Specificity: AA 76-143

Purpose: Mouse monoclonal antibody raised against a partial recombinant AKR1B10.

Sequence: VSKLWPTFFE RPLVRKAFEK TLKDLKLSYL DVYLIHWPQG FKSGDDLFPK DDKGNAIGGK ATFLDAWE

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: AKR1B10 (NP_064695, 76 a.a. ~ 143 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AKR1B10 antibody (ABIN566074)

Berard, Coombs, Severini: "Quantification of the host response proteome after herpes simplex virus type 1 infection." in: Journal of proteome research, Vol. 14, Issue 5, pp. 2121-42, (2015) (PubMed).

Matkowskyj, Bai, Liao, Zhang, Li, Rao, Omary, Yang: "Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions." in: Human pathology, Vol. 45, Issue 4, pp. 834-43, (2014) (PubMed).

Chung, Matkowskyj, Li, Bai, Zhang, Tsao, Liao, Yang: "Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 25, Issue 5, pp. 758-66, (2012) (PubMed).

Moriguchi, Zhang, Mihara, Sato: "A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals." in: Scientific reports, Vol. 2, pp. 280, (2012) (PubMed).

Nelson, Pillay, Henderson, Presneau, Tirabosco, Halai, Berisha, Flicek, Stemple, Stern, Wardle, Flanagan: "An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma." in: The Journal of pathology, Vol. 228, Issue 3, pp. 274-85, (2012) (PubMed).

Schmitz, Sotiropoulos, Baba, Schmid, Müller, Paul, Auer, Gamerith, Loeffler-Ragg: "AKR1B10 expression is associated with less aggressive hepatocellular carcinoma: a clinicopathological study of 168 cases." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 31, Issue 6, pp. 810-6, (2011) (PubMed).

Bains, Grigliatti, Reid, Riggs: "Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin." in: The Journal of pharmacology and experimental therapeutics, Vol. 335, Issue 3, pp. 533-45, (2010) (PubMed).

Satow, Shitashige, Kanai, Takeshita, Ojima, Jigami, Honda, Kosuge, Ochiya, Hirohashi, Yamada: "Combined functional genome survey of therapeutic targets for hepatocellular carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 9, pp. 2518-28, (2010) (PubMed).

Target Details for AKR1B10

Target: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Alternative Name: AKR1B10

Background: Full Gene Name: aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms: AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1,HIS,HSI,MGC14103

Gene ID: 57016

NCBI Accession: NM_020299