ALKBH7 antibody (AA 1-221)

Catalog No. ABIN5664063

This Rabbit Polyclonal antibody specifically detects ALKBH7 in WB. It exhibits reactivity toward Human.

Quick Overview for ALKBH7 antibody (AA 1-221) (ABIN5664063)

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALKBH7 Antibody

Binding Specificity: AA 1-221

Sequence: MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ALKBH7

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Alternative Name: ALKBH7

Background: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7

Molecular Weight: 24 kDa

Gene ID: 84266

UniProt: Q9BT30