Recombinant RSV (Felvizumab Biosimilar) antibody

Catalog No. ABIN5668206

The Human Monoclonal anti-RSV (Felvizumab Biosimilar) antibody has been validated for ELISA and Func. It is suitable to detect RSV (Felvizumab Biosimilar) in samples from Respiratory Syncytial Virus (RSV).

Quick Overview for Recombinant RSV (Felvizumab Biosimilar) antibody (ABIN5668206)

Target: RSV (Felvizumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Respiratory Syncytial Virus (RSV)

Host: Human

Clonality: Monoclonal

Conjugate: This RSV (Felvizumab Biosimilar) antibody is un-conjugated

Application: ELISA, Functional Studies (Func)

Clone: RSHZ19

Product Details anti-RSV (Felvizumab Biosimilar) Antibody

Purpose: Anti-RSV [RSHZ19 (Felvizumab)], Human IgG1, kappa

Specificity: This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

Isotype: IgG1 kappa

Application Details

Application Notes: Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for RSV (Felvizumab Biosimilar)

Target: RSV (Felvizumab Biosimilar)

Target Type: Biosimilar

Background: SB 209763, respiratory syncytial virus