RAD51D antibody (AA 1-100) (HRP)

Catalog No. ABIN5675751

This Rabbit Polyclonal antibody specifically detects RAD51D in WB, ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for RAD51D antibody (AA 1-100) (HRP) (ABIN5675751)

Target: RAD51D (RAD51 Homolog D (RAD51D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51D antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RAD51D Antibody (HRP)

Binding Specificity: AA 1-100

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAD51D

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RAD51D

Target: RAD51D (RAD51 Homolog D (RAD51D))

Alternative Name: RAD51D

Background:

Synonyms: DNA repair protein RAD51 homolog 4, RAD51D, R51H3, RAD51 homolog D RAD51-like protein 3, TRAD, RAD51D, RAD51L3

Background: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene ID: 5892

UniProt: O75771