Peripherin antibody

Catalog No. ABIN5687475

This Chicken Polyclonal antibody specifically detects Peripherin in WB and IHC. It exhibits reactivity toward Mammalian.

Quick Overview for Peripherin antibody (ABIN5687475)

Target: Peripherin (PRPH)

Reactivity: Mammalian

Host: Chicken

Clonality: Polyclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Peripherin Antibody

Specificity: Specific for the ~57  kDa peripherin protein.

Purification: Total IgY fraction

Immunogen: Recombinant rat peripherin expressed in and purified from E. coli.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Storage Comment: Peripherin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: Peripherin

Background: Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.

Molecular Weight: 57 kDa

Gene ID: 24688

UniProt: P21807