ATM Interactor antibody (AA 200-250)

Catalog No. ABIN5689887

This Rabbit Polyclonal antibody specifically detects ATM Interactor in WB, ELISA, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ATM Interactor antibody (AA 200-250) (ABIN5689887)

Target: ATM Interactor (ATMIN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATM Interactor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-ATM Interactor Antibody

Binding Specificity: AA 200-250

Specificity: ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.

Purification: ATMIN antibody is affinity chromatography purified via peptide column.

Immunogen: ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN.

The immunogen is located within amino acids 200 - 250 of ATMIN.

Isotype: IgG

Application Details

Application Notes: ATMIN antibody can be used for detection of ATMIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 2.5 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATMIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: ATMIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ATM Interactor

Target: ATM Interactor (ATMIN)

Alternative Name: ATMIN

Background: The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).

Molecular Weight: Predicted: 73, 79, 91 kDa

Observed: 72 kDa

Gene ID: 23300

NCBI Accession: NP_056066

UniProt: O43313