SNRPE antibody (AA 330-380)

Catalog No. ABIN5689894

The Rabbit Polyclonal anti-SNRPE antibody is suitable to detect SNRPE in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for SNRPE antibody (AA 330-380) (ABIN5689894)

Target: SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNRPE antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SNRPE Antibody

Binding Specificity: AA 330-380

Specificity: At least two isoforms of B-raf are known to exist, this antibody will detect both isoforms. This antibody will not cross-react with C-raf.

Purification: B-raf Antibody is affinity chromatography purified via peptide column.

Immunogen: B-raf antibody was raised against a 19 amino acid peptide near the center of human B-raf.

The immunogen is located within amino acids 330 - 380 of B-raf.

Isotype: IgG

Application Details

Application Notes: B-raf antibody can be used for detection of B-raf by Western blot at 1 and 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: B-raf Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: B-raf antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SNRPE

Target: SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE))

Alternative Name: B-raf

Background: B-raf Antibody: B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease characterized by heart defects, mental retardation and a distinctive facial appearance.

Molecular Weight: Predicted: 84

Observed: 99, multiple post-translational modifications, commonly observed at 95-100kDa

Gene ID: 673

UniProt: P15056

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C