Neurexin 1 antibody (AA 141-294) (DyLight 488)

Catalog No. ABIN7354637

The Rabbit Polyclonal anti-Neurexin 1 antibody has been validated for FACS. It is suitable to detect Neurexin 1 in samples from Human.

Quick Overview for Neurexin 1 antibody (AA 141-294) (DyLight 488) (ABIN7354637)

Target: Neurexin 1 (NRXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurexin 1 antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Product Details anti-Neurexin 1 Antibody (DyLight 488)

Binding Specificity: AA 141-294

Purpose: Anti-Human Neurexin 1 DyLight® 488 conjugated NRXN1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human Neurexin 1 DyLight® 488 conjugated NRXN1 Antibody -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Comoletti, Davide, Flynn Robyn, Jennings Lori L, Chubykin Alexander, Matsumura Takehito, Hasegawa Hana, Südhof Thomas C, Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497-50505. 2. Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032-26039.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for Neurexin 1

Target: Neurexin 1 (NRXN1)

Alternative Name: NRXN1

Background:

Synonyms: Neurexin-1-beta, Neurexin I-beta, NRXN1

Tissue Specificity: Liver.

Background: Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Molecular Weight: 39 kDa

Gene ID: 9378

UniProt: P58400

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development