IL-10RA antibody

Catalog No. ABIN5698000

This Rabbit Polyclonal antibody specifically detects IL-10RA in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for IL-10RA antibody (ABIN5698000)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-10RA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-IL-10RA Antibody

Purpose: IL10RA antibody

Immunogen: interleukin 10 receptor, alpha

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Alternative Name: IL10RA

Background:

Synonyms: Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA)|CDw210a|Interleukin-10 receptor subunit 1 (IL-10R subunit 1, IL-10R1)|IL10RA|IL10R

Background: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Molecular Weight: 70-72 kDa,90-95 kDa

Gene ID: 3587

UniProt: Q13651

Pathways: Growth Factor Binding