GAP43 antibody

Catalog No. ABIN576411

This anti-GAP43 antibody is a Mouse Monoclonal antibody detecting GAP43 in IHC, IHC (p), FACS and IHC (fro). Suitable for Rat, Mouse and Chicken.

Quick Overview for GAP43 antibody (ABIN576411)

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Reactivity: Rat, Mouse, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This GAP43 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GAP43 Antibody

Specificity: Recognizes a protein originally termed 2G13P which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kD laminin receptor precursor or Laminin receptor 1. 40S ribosomal protein SA is a 296 amino acid ~37kD membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor. In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture. 40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility. Has been used for the detection of growth cones by immunohistochemistry and identification of 40S ribosomal protein SA by western blotting in chicken and rat samples.

Immunogen: Embryonic chick tectal membranes.

Type of Immunogen: Membrane fraction

Isotype: IgM

Application Details

Application Notes: Approved: Flo, IHC, IHC-Fr, IHC-P

Usage: Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

Comment:

Target Species of Antibody: Chicken

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tissue culture supernatant, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for GAP43

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Alternative Name: GAP43

Background: Name/Gene ID: GAP43
Family: Neuromodulin

Synonyms: GAP43, Axonal membrane protein GAP-43, B-50, Growth associated protein 43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46, GAP-43, Protein F1

Gene ID: 2596