ING2 antibody (AA 1-280)

Catalog No. ABIN5776013

This anti-ING2 antibody is a Mouse Monoclonal antibody detecting ING2 in WB, ELISA, IF and ICC. Suitable for Human.

Quick Overview for ING2 antibody (AA 1-280) (ABIN5776013)

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ING2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT39E5

Product Details anti-ING2 Antibody

Binding Specificity: AA 1-280

Purpose: Human ING2 antibody

Purification: Purified

Immunogen: Recombinant human ING2 (1-280aa) purified from E. coli

Isotype: IgG1b kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Alternative Name: ING2

Background: ING2 is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. This protein seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Also, It is component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides.

NCBI Accession: NP_001555

Pathways: Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling