YWHAE antibody (AA 1-255)

Catalog No. ABIN5776144

The Mouse Monoclonal anti-YWHAE antibody has been validated for WB, ELISA, IF and ICC. It is suitable to detect YWHAE in samples from Human.

Quick Overview for YWHAE antibody (AA 1-255) (ABIN5776144)

Target: YWHAE (14-3-3 epsilon (YWHAE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YWHAE antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: AT4F8

Product Details anti-YWHAE Antibody

Binding Specificity: AA 1-255

Immunogen: Recombinant human14-3-3 epsilon (1-255aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for YWHAE

Target: YWHAE (14-3-3 epsilon (YWHAE))

Alternative Name: 14-3-3 epsilon

Background: The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

NCBI Accession: NP_006752

Pathways: Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase