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IGF2R antibody (Insulin-Like Growth Factor 2 Receptor) (PE) Primary Antibody

IGF2R Reactivity: Human, Non-Human Primate FACS, IP, WB Host: Mouse Monoclonal MEM-238 PE
Pubmed (2)
Catalog No. ABIN609650
$528.26
Plus shipping costs $45.00
100 tests
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Delivery in 5 to 7 Business Days
  • Target
    IGF2R
    Reactivity
    • 87
    • 36
    • 19
    • 8
    • 5
    • 4
    • 3
    • 3
    • 1
    Human, Non-Human Primate
    Host
    • 62
    • 30
    Mouse
    Clonality
    • 63
    • 29
    Monoclonal
    Conjugate
    • 45
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGF2R antibody is conjugated to PE
    Application
    • 45
    • 39
    • 25
    • 23
    • 13
    • 13
    • 13
    • 12
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Specificity
    The antibody MEM-238 recognizes an epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
    HLDA VII, WS Code 70640
    Cross-Reactivity (Details)
    Human, Non-Human Primates
    Immunogen
    Recombinant Vaccinia virus encoding CD222.
    Clone
    MEM-238
    Isotype
    IgG1
  • Application Notes
    The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.
    Comment

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Avoid prolonged exposure to light.
    Storage
    4 °C
    Storage Comment
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, 2015 (PubMed).

    Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, 2002 (PubMed).

  • Target
    IGF2R
    Alternative Name
    CD222 (IGF2R Antibody Abstract)
    Synonyms
    CD222, CIMPR, M6P-R, MPR1, MPRI, AI661837, CI-MPR, M6P/IGF2R, Mpr300, mpri, cd222, cimpr, m6p-r, insulin like growth factor 2 receptor, insulin-like growth factor 2 receptor, IGF2R, Igf2r, igf2r
    Background
    CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
    Gene ID
    3482
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