ICOS antibody (APC)

Catalog No. ABIN610261

This Mouse Monoclonal antibody specifically detects ICOS in FACS, ELISA, Func. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for ICOS antibody (APC) (ABIN610261)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICOS antibody is conjugated to APC

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: ANC6C6-A3

Product Details anti-ICOS Antibody (APC)

Specificity: Recombinant and cell surface CD278 (ICOS).

Purification: Gel filtration

Immunogen: Human HPB-MLT cells, recombinant human CD278(ICOS)-muIg.

Isotype: IgG1 kappa

Application Details

Application Notes: Approved: ELISA, Flo, Func

Usage: Function: Blocks binding of Recombinant CD275-muIg to CD278. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 500 mM potassium chloride, 150 mM sodium chloride, 15 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-ICOS antibody (APC) (ABIN610261)

Fusaro, Wang, Chellappan: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).

Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: ICOS / CD278

Background: Name/Gene ID: ICOS

Synonyms: ICOS, AILIM, CD278, CVID1, Inducible costimulator, Inducible T-cell co-stimulator, CD278 antigen, Inducible T-cell costimulator

Gene ID: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints