Aggrecan antibody (AA 20-280)

Catalog No. ABIN6136406

The Rabbit Polyclonal anti-Aggrecan antibody has been validated for WB, IHC and IF. It is suitable to detect Aggrecan in samples from Human.

Quick Overview for Aggrecan antibody (AA 20-280) (ABIN6136406)

Target: Aggrecan (ACAN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aggrecan antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Aggrecan Antibody

Binding Specificity: AA 20-280

Sequence: VETSDHDNSL SVSIPQPSPL RVLLGTSLTI PCYFIDPMHP VTTAPSTAPL APRIKWSRVS KEKEVVLLVA TEGRVRVNSA YQDKVSLPNY PAIPSDATLE VQSLRSNDSG VYRCEVMHGI EDSEATLEVV VKGIVFHYRA ISTRYTLDFD RAQRACLQNS AIIATPEQLQ AAYEDGFHQC DAGWLADQTV RYPIHTPREG CYGDKDEFPG VRTYGIRDTN ETYDVYCFAE EMEGEVFYAT SPEKFTFQEA ANECRRLGAR L

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human Aggrecan (NP_001126.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Aggrecan

Target: Aggrecan (ACAN)

Alternative Name: ACAN

Background: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.,ACAN,AGC1,AGCAN,CSPG1,CSPGCP,MSK16,SEDK,aggrecan,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Stem Cells,Mesenchymal Stem Cells,ACAN

Molecular Weight: 239 kDa/246 kDa/250 kDa

Gene ID: 176

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport