ALKBH4 antibody (AA 1-302)

Catalog No. ABIN6136802

This Rabbit Polyclonal antibody specifically detects ALKBH4 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for ALKBH4 antibody (AA 1-302) (ABIN6136802)

Target: ALKBH4 (AlkB, Alkylation Repair Homolog 4 (E. Coli) (ALKBH4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ALKBH4 Antibody

Binding Specificity: AA 1-302

Sequence: MAAAAAETPE VLRECGCKGI RTCLICERQR GSDPPWELPP AKTYRFIYCS DTGWAVGTEE SDFEGWAFPF PGVMLIEDFV TREEEAELVR LMDRDPWKLS QSGRRKQDYG PKVNFRKQKL KTEGFCGLPS FSREVVRRMG LYPGLEGFRP VEQCNLDYCP ERGSAIDPHL DDAWLWGERL VSLNLLSPTV LSMCREAPGS LLLCSAPSAA PEALVDSVIA PSRSVLCQEV EVAIPLPARS LLVLTGAARH QWKHAIHRRH IEARRVCVTF RELSAEFGPG GRQQELGQEL LRIALSFQGR PV

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human ALKBH4 (NP_060091.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ALKBH4

Target: ALKBH4 (AlkB, Alkylation Repair Homolog 4 (E. Coli) (ALKBH4))

Alternative Name: ALKBH4

Background: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1, thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6-methyladenosine DNA, thereby regulating Polycomb silencing (By similarity.,ALKBH4,ABH4,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH4

Molecular Weight: 4 kDa/33 kDa

Gene ID: 54784

UniProt: Q9NXW9