ASCC2 antibody (AA 488-757)

Catalog No. ABIN6137169

This anti-ASCC2 antibody is a Rabbit Polyclonal antibody detecting ASCC2 in WB and IHC. Suitable for Human.

Quick Overview for ASCC2 antibody (AA 488-757) (ABIN6137169)

Target: ASCC2 (Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASCC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ASCC2 Antibody

Binding Specificity: AA 488-757

Sequence: LACLEYYHYD PEQVINNILE ERLAPTLSQL DRNLDREMKP DPTPLLTSRH NVFQNDEFDV FSRDSVDLSR VHKGKSTRKE ENTRSLLNDK RAVAAQRQRY EQYSVVVEEV PLQPGESLPY HSVYYEDEYD DTYDGNQVGA NDADSDDELI SRRPFTIPQV LRTKVPREGQ EEDDDDEEDD ADEEAPKPDH FVQDPAVLRE KAEARRMAFL AKKGYRHDSS TAVAGSPRGH GQSRETTQER RKKEANKATR ANHNRRTMAD RKRSKGMIPS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 488-757 of human ASCC2 (NP_115580.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ASCC2

Target: ASCC2 (Activating Signal Cointegrator 1 Complex Subunit 2 (ASCC2))

Alternative Name: ASCC2

Background: Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity.,ASCC2,ASC1p100,p100,Signal Transduction,ASCC2

Molecular Weight: 41 kDa/77 kDa/86 kDa

Gene ID: 84164

UniProt: Q9H1I8