Ataxin 1 antibody (AA 586-815)

Catalog No. ABIN6137363

This anti-Ataxin 1 antibody is a Rabbit Polyclonal antibody detecting Ataxin 1 in WB. Suitable for Human.

Quick Overview for Ataxin 1 antibody (AA 586-815) (ABIN6137363)

Target: Ataxin 1 (ATXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Ataxin 1 Antibody

Binding Specificity: AA 586-815

Sequence: ELKKVEDLKT EDFIQSAEIS NDLKIDSSTV ERIEDSHSPG VAVIQFAVGE HRAQVSVEVL VEYPFFVFGQ GWSSCCPERT SQLFDLPCSK LSVGDVCISL TLKNLKNGSV KKGQPVDPAS VLLKHSKADG LAGSRHRYAE QENGINQGSA QMLSENGELK FPEKMGLPAA PFLTKIEPSK PAATRKRRWS APESRKLEKS EDEPPLTLPK PSLIPQEVKI CIEGRSNVGK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: ATXN1

Background: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.,ATXN1,ATX1,D6S504E,SCA1,ataxin-1,Epigenetics & Nuclear Signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Neuroscience,Neurodegenerative Diseases,ATXN1

Molecular Weight: 86 kDa

Gene ID: 6310

UniProt: P54253

Pathways: Synaptic Membrane